MMS19 antibody

Catalog No. ABIN7116477

The Mouse Monoclonal anti-MMS19 antibody (Clone 6H1) (ABIN7116477) specifically detects MMS19 in WB, ELISA, IF and IHC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for MMS19 antibody (ABIN7116477)

Target: MMS19 (MMS19 Nucleotide Excision Repair Homolog (MMS19))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This MMS19 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

Clone: 6H1

Product Details anti-MMS19 Antibody

Purpose: MMS19 antibody

Purification: Protein A+G purification

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: MMS19 nucleotide excision repair homolog

Isotype: IgG2a

Application Details

Application Notes: WB: 1:1000-1:4000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for MMS19

Target: MMS19 (MMS19 Nucleotide Excision Repair Homolog (MMS19))

Alternative Name: MMS19

Background:

Synonyms: MMS19 nucleotide excision repair protein homolog (hMMS19)|MET18 homolog|MMS19-like protein|MMS19|MMS19L

Background: Key component of the cytosolic iron-sulfur protein assembly(CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair(NER) and RNA polymerase II(POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor(ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery.

Molecular Weight: 103 kDa

Gene ID: 64210

UniProt: Q96T76

Pathways: Nuclear Hormone Receptor Binding