NMNAT3 antibody

Catalog No. ABIN7116866

The Rabbit Polyclonal anti-NMNAT3 antibody has been validated for ELISA and WB. It is suitable to detect NMNAT3 in samples from Human, Mouse and Rat.

Quick Overview for NMNAT3 antibody (ABIN7116866)

Target: NMNAT3 (Nicotinamide Nucleotide Adenylyltransferase 3 (NMNAT3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NMNAT3 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-NMNAT3 Antibody

Purpose: NMNAT3 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: nicotinamide nucleotide adenylyltransferase 3

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for NMNAT3

Target: NMNAT3 (Nicotinamide Nucleotide Adenylyltransferase 3 (NMNAT3))

Alternative Name: NMNAT3

Background:

Synonyms: Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 (NMN/NaMN adenylyltransferase 3)|Nicotinamide-nucleotide adenylyltransferase 3 (NMN adenylyltransferase 3)|Nicotinate-nucleotide adenylyltransferase 3 (NaMN adenylyltransferase 3)|Pyridine nucleotide adenylyltransferase 3 (PNAT-3)|NMNAT3

Background: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide(NMN) and ATP. Can also use the deamidated form, nicotinic acid mononucleotide(NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate(TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate(NHD), nicotinamide guanine dinucleotide(NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury.

Molecular Weight: 24-28 kDa

Gene ID: 349565

UniProt: Q96T66