NMRAL1 antibody

Catalog No. ABIN7116912

This anti-NMRAL1 antibody is a Rabbit Polyclonal antibody detecting NMRAL1 in ELISA, WB and IHC. Suitable for Human, Rat and Mouse.

Quick Overview for NMRAL1 antibody (ABIN7116912)

Target: NMRAL1 (NmrA-Like Family Domain Containing 1 (NMRAL1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NMRAL1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-NMRAL1 Antibody

Purpose: NMRAL1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: NmrA-like family domain containing 1

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for NMRAL1

Target: NMRAL1 (NmrA-Like Family Domain Containing 1 (NMRAL1))

Alternative Name: NMRAL1

Background:

Synonyms: NmrA-like family domain-containing protein 1|NMRAL1|HSCARG

Background: Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase(ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer.

Molecular Weight: 33 kDa

Gene ID: 57407

UniProt: Q9HBL8