NOTCH3 antibody

Catalog No. ABIN7116933

This anti-NOTCH3 antibody is a Rabbit Polyclonal antibody detecting NOTCH3 in WB, ELISA, IHC and IP. Suitable for Human, Mouse and Rat.

Quick Overview for NOTCH3 antibody (ABIN7116933)

Target: NOTCH3 (Notch 3 (NOTCH3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NOTCH3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Product Details anti-NOTCH3 Antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: Notch homolog 3

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:500-1:1000, IHC: 1:50-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for NOTCH3

Target: NOTCH3 (Notch 3 (NOTCH3))

Alternative Name: NOTCH3

Background: Synonyms:CADASIL, CASIL, Notch 3, Notch homolog 3, NOTCH3 Background:Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain(NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs(By similarity).

Molecular Weight: 250-260 kDa, 100 kDa

Gene ID: 4854

UniProt: Q9UM47

Pathways: Notch Signaling