Nth Endonuclease III-Like 1 (NTHL1) antibody

Catalog No. ABIN7116939

The Rabbit Polyclonal anti-Nth Endonuclease III-Like 1 antibody (ABIN7116939) specifically detects Nth Endonuclease III-Like 1 in WB, ELISA and IHC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Nth Endonuclease III-Like 1 (NTHL1) antibody (ABIN7116939)

Target: Nth Endonuclease III-Like 1 (NTHL1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details

Purpose: NTHL1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: nth endonuclease III-like 1(E. coli)

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details

Target: Nth Endonuclease III-Like 1 (NTHL1)

Alternative Name: NTHL1

Background:

Synonyms: Endonuclease III-like protein 1 (hNTH1)|Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase (DNA glycosylase/AP lyase)|NTHL1|NTH1|OCTS3

Background: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic(AP) lyase function that catalyzes the first step in base excision repair(BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Has also 8-oxo-7,8-dihydroguanine(8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Is able to process lesions in nucleosomes without requiring or inducing nucleosome disruption.

Molecular Weight: 34 kDa

Gene ID: 4913

UniProt: P78549