NFIL3 antibody

Catalog No. ABIN7116970

This Rabbit Polyclonal antibody specifically detects NFIL3 in WB, ELISA and IP. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for NFIL3 antibody (ABIN7116970)

Target: NFIL3 (Nuclear Factor, Interleukin 3 Regulated (NFIL3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NFIL3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Product Details anti-NFIL3 Antibody

Purpose: NFIL3 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: nuclear factor, interleukin 3 regulated

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:200-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for NFIL3

Target: NFIL3 (Nuclear Factor, Interleukin 3 Regulated (NFIL3))

Alternative Name: NFIL3

Background:

Synonyms: Nuclear factor interleukin-3-regulated protein|E4 promoter-binding protein 4|Interleukin-3 promoter transcriptional activator|Interleukin-3-binding protein 1|Transcriptional activator NF-IL3A|NFIL3|E4BP4|IL3BP1

Background: Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor(ATF) sites. Represses promoter activity in osteoblasts(By similarity). Represses transcriptional activity of PER1(By similarity). Represses transcriptional activity of PER2 via the B-site on the promoter(By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors(DBP, HLF and TEF)(By similarity). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock(By similarity). Protects pro-B cells from programmed cell death(By similarity).

Molecular Weight: 55-60 kDa

Gene ID: 4783

UniProt: Q16649