NUMBL antibody

Catalog No. ABIN7117091

The Rabbit Polyclonal anti-NUMBL antibody has been validated for WB, ELISA, IHC, IP and IF. It is suitable to detect NUMBL in samples from Human, Mouse and Rat.

Quick Overview for NUMBL antibody (ABIN7117091)

Target: NUMBL (Numb Homolog (Drosophila)-Like (NUMBL))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NUMBL antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Product Details anti-NUMBL Antibody

Purpose: NUMBL antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: numb homolog(Drosophila)-like

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:200-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for NUMBL

Target: NUMBL (Numb Homolog (Drosophila)-Like (NUMBL))

Alternative Name: NUMBL

Background:

Synonyms: Numb-like protein|Numb-related protein (Numb-R)|NUMBL

Background: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells(RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone(SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.

Molecular Weight: 65-70 kDa

Gene ID: 9253

UniProt: Q9Y6R0

Pathways: Cell-Cell Junction Organization