OCRL antibody

Catalog No. ABIN7117103

The Rabbit Polyclonal anti-OCRL antibody is suitable to detect OCRL in samples from Human, Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for OCRL antibody (ABIN7117103)

Target: OCRL (Oculocerebrorenal Syndrome of Lowe (OCRL))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This OCRL antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-OCRL Antibody

Purpose: OCRL antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: oculocerebrorenal syndrome of Lowe

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for OCRL

Target: OCRL (Oculocerebrorenal Syndrome of Lowe (OCRL))

Alternative Name: OCRL

Background:

Synonyms: Inositol polyphosphate 5-phosphatase OCRL|Inositol polyphosphate 5-phosphatase OCRL-1 (OCRL-1)|Lowe oculocerebrorenal syndrome protein|Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase|OCRL|OCRL1

Background: Converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Also converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate(PubMed:25869668, PubMed:7761412, PubMed:9430698). May function in lysosomal membrane trafficking by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with lysosomes. Involved in primary cilia assembly(PubMed:22228094, PubMed:22543976).

Molecular Weight: 105 kDa

Gene ID: 4952

UniProt: Q01968

Pathways: Inositol Metabolic Process