PAN2 antibody

Catalog No. ABIN7117214

The Rabbit Polyclonal anti-PAN2 antibody is suitable to detect PAN2 in samples from Human, Mouse and Rat. It has been validated for ELISA, WB and IHC.

Quick Overview for PAN2 antibody (ABIN7117214)

Target: PAN2 (PAN2 Poly(A) Specific Ribonuclease Subunit Homolog (PAN2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAN2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-PAN2 Antibody

Purpose: PAN2 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: PAN2 poly(A) specific ribonuclease subunit homolog

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for PAN2

Target: PAN2 (PAN2 Poly(A) Specific Ribonuclease Subunit Homolog (PAN2))

Alternative Name: PAN2

Background:

Synonyms: PAN2-PAN3 deadenylation complex catalytic subunit PAN2|Inactive ubiquitin carboxyl-terminal hydrolase 52|PAB1P-dependent poly(A)-specific ribonuclease|Poly(A)-nuclease deadenylation complex subunit 2 (PAN deadenylation complex subunit 2)|PAN2|KIAA0710|USP52

Background: Catalytic subunit of the poly(A)-nuclease(PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein(PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1.

Molecular Weight: 127 kDa

Gene ID: 9924

UniProt: Q504Q3