PARP3 antibody

Catalog No. ABIN7117630

This Rabbit Polyclonal antibody specifically detects PARP3 in ELISA, WB, IHC and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for PARP3 antibody (ABIN7117630)

Target: PARP3 (Poly (ADP-Ribose) Polymerase Family, Member 3 (PARP3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PARP3 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-PARP3 Antibody

Purpose: PARP3 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: poly(ADP-ribose) polymerase family, member 3

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for PARP3

Target: PARP3 (Poly (ADP-Ribose) Polymerase Family, Member 3 (PARP3))

Alternative Name: PARP3

Background:

Synonyms: Protein mono-ADP-ribosyltransferase PARP3|ADP-ribosyltransferase diphtheria toxin-like 3 (ARTD3)|DNA ADP-ribosyltransferase PARP3|IRT1|NAD(+) ADP-ribosyltransferase 3 (ADPRT-3)|Poly [ADP-ribose] polymerase 3 (PARP-3, hPARP-3)|Poly[ADP-ribose] synthase 3 (pADPRT-3)|PARP3|ADPRT3|ADPRTL3

Background: Involved in the base excision repair(BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.

Molecular Weight: 60-62 kDa

Gene ID: 10039

UniProt: Q9Y6F1