PARP3 antibody (N-Term)

Catalog No. ABIN1881632

Product Details anti-PARP3 Antibody

Target: PARP3 (Poly (ADP-Ribose) Polymerase Family, Member 3 (PARP3))

Binding Specificity: AA 99-126, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PARP3 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PARP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 99-126 amino acids from the N-terminal region of human PARP3.

Clone: RB42819

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for PARP3

Target: PARP3 (Poly (ADP-Ribose) Polymerase Family, Member 3 (PARP3))

Alternative Name: PARP3 (PARP3 Products)

Synonyms: ADPRT-3 antibody, PARP-3 antibody, PM38 antibody, Adprtl3 antibody, fj17c06 antibody, wu:fj17c06 antibody, zgc:66157 antibody, PARP3 antibody, parp3 antibody, ADPRT3 antibody, ADPRTL2 antibody, ADPRTL3 antibody, ARTD3 antibody, IRT1 antibody, PADPRT-3 antibody, A930002C11Rik antibody, AW990611 antibody, Adprt3 antibody, pADPRT-3 antibody, seed maturation protein PM38 antibody, poly (ADP-ribose) polymerase family, member 3 antibody, poly(ADP-ribose) polymerase family member 3 antibody, poly(ADP-ribose) polymerase family member 3 L homeolog antibody, PARP3 antibody, parp3 antibody, parp3.L antibody, Parp3 antibody

Background: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.

Molecular Weight: 60089

NCBI Accession: NP_001003931, NP_005476

UniProt: Q9Y6F1