POLR3D antibody

Catalog No. ABIN7117681

This Rabbit Polyclonal antibody specifically detects POLR3D in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for POLR3D antibody (ABIN7117681)

Target: POLR3D (Polymerase (RNA) III (DNA Directed) Polypeptide D, 44kDa (POLR3D))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This POLR3D antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-POLR3D Antibody

Purpose: POLR3D antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: polymerase(RNA) III(DNA directed) polypeptide D, 44kDa

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for POLR3D

Target: POLR3D (Polymerase (RNA) III (DNA Directed) Polypeptide D, 44kDa (POLR3D))

Alternative Name: POLR3D

Background:

Synonyms: DNA-directed RNA polymerase III subunit RPC4 (RNA polymerase III subunit C4)|DNA-directed RNA polymerase III subunit D|Protein BN51|RNA polymerase III 47 kDa subunit|RPC53 homolog|POLR3D|BN51|BN51T

Background: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs(EBERs) induce type I interferon and NF-Kappa-B through the RIG-I pathway(By similarity).

Molecular Weight: 44 kDa

Gene ID: 661

UniProt: P05423