PDIA3 antibody

Catalog No. ABIN7117935

This anti-PDIA3 antibody is a Rabbit Polyclonal antibody detecting PDIA3 in WB, IHC, ELISA, IP, IF and FACS. Suitable for Human, Mouse and Rat.

Quick Overview for PDIA3 antibody (ABIN7117935)

Target: PDIA3 (Protein Disulfide Isomerase Family A, Member 3 (PDIA3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDIA3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-PDIA3 Antibody

Purpose: PDIA3 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: protein disulfide isomerase family A, member 3

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2400, IP: 1:1000-1:4000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for PDIA3

Target: PDIA3 (Protein Disulfide Isomerase Family A, Member 3 (PDIA3))

Alternative Name: PDIA3

Background:

Synonyms: Protein disulfide-isomerase A3|58 kDa glucose-regulated protein|58 kDa microsomal protein (p58)|Disulfide isomerase ER-60|Endoplasmic reticulum resident protein 57 (ER protein 57, ERp57)|Endoplasmic reticulum resident protein 60 (ER protein 60, ERp60)|PDIA3|ERP57|ERP60|GRP58

Background: PDIA3, also named as P58, ER60, ERp57, ERp60, ERp61, GRP57, GRP58 and PI-PLC, is a member of the PDI family, participates in the oxidation, reduction, and isomerization of disulfide bonds for correct folding of secretory proteins before modification and transport in the endoplasmic reticulum. It is associated with apoptosis or inhibition of cancer cell growth. PDIA3 was once thought to be a phospholipase, however, it has been demonstrated that this protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and PDIA3 mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates.

Molecular Weight: 57 kDa

UniProt: P30101

Pathways: Maintenance of Protein Location, Protein targeting to Nucleus, Cell RedoxHomeostasis