PKMYT1 antibody

Catalog No. ABIN7117978

This Rabbit Polyclonal antibody specifically detects PKMYT1 in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for PKMYT1 antibody (ABIN7117978)

Target: PKMYT1 (Protein Kinase, Membrane Associated tyrosine/threonine 1 (PKMYT1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PKMYT1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-PKMYT1 Antibody

Purpose: PKMYT1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: protein kinase, membrane associated tyrosine/threonine 1

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for PKMYT1

Target: PKMYT1 (Protein Kinase, Membrane Associated tyrosine/threonine 1 (PKMYT1))

Alternative Name: PKMYT1

Background:

Synonyms: Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase|Myt1 kinase|PKMYT1|MYT1

Background: Acts as a negative regulator of entry into mitosis(G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.

Molecular Weight: 55 kDa

Gene ID: 9088

UniProt: Q99640

Pathways: Mitotic G1-G1/S Phases, M Phase