PPP1R9B antibody

Catalog No. ABIN7118007

The Rabbit Polyclonal anti-PPP1R9B antibody (ABIN7118007) specifically detects PPP1R9B in WB, ELISA, IHC and IP. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for PPP1R9B antibody (ABIN7118007)

Target: PPP1R9B (Protein Phosphatase 1, Regulatory Subunit 9B, Spinophilin (PPP1R9B))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPP1R9B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Product Details anti-PPP1R9B Antibody

Purpose: PPP1R9B antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: protein phosphatase 1, regulatory(inhibitor) subunit 9B

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for PPP1R9B

Target: PPP1R9B (Protein Phosphatase 1, Regulatory Subunit 9B, Spinophilin (PPP1R9B))

Alternative Name: PPP1R9B

Background:

Synonyms: Neurabin-2|Neurabin-II|Protein phosphatase 1 regulatory subunit 9B|Spinophilin|PPP1R9B|PPP1R6

Background: Seems to act as a scaffold protein in multiple signaling pathways. Modulates excitatory synaptic transmission and dendritic spine morphology. Binds to actin filaments(F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May play an important role in linking the actin cytoskeleton to the plasma membrane at the synaptic junction. Believed to target protein phosphatase 1/PP1 to dendritic spines, which are rich in F-actin, and regulates its specificity toward ion channels and other substrates, such as AMPA-type and NMDA-type glutamate receptors. Plays a role in regulation of G-protein coupled receptor signaling, including dopamine D2 receptors and alpha-adrenergic receptors. May establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors downstream signaling molecules and the actin cytoskeleton. Binds to ADRA1B and RGS2 and mediates regulation of ADRA1B signaling. May confer to Rac signaling specificity by binding to both, RacGEFs and Rac effector proteins. Probably regulates p70 S6 kinase activity by forming a complex with TIAM1(By similarity). Required for hepatocyte growth factor(HGF)-induced cell migration.

Molecular Weight: 120-130 kDa

Gene ID: 84687

UniProt: Q96SB3

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling