PTPMT1 antibody

Catalog No. ABIN7118052

The Rabbit Polyclonal anti-PTPMT1 antibody (ABIN7118052) specifically detects PTPMT1 in ELISA, WB and IHC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for PTPMT1 antibody (ABIN7118052)

Target: PTPMT1 (Protein Tyrosine Phosphatase, Mitochondrial 1 (PTPMT1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTPMT1 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-PTPMT1 Antibody

Purpose: PTPMT1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: protein tyrosine phosphatase, mitochondrial 1

Isotype: IgG

Application Details

Application Notes: WB: 1:200-1:1000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for PTPMT1

Target: PTPMT1 (Protein Tyrosine Phosphatase, Mitochondrial 1 (PTPMT1))

Alternative Name: PTPMT1

Background:

Synonyms: Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1|PTEN-like phosphatase|Phosphoinositide lipid phosphatase|Protein-tyrosine phosphatase mitochondrial 1|PTPMT1|MOSP|PLIP

Background: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate(PGP) to phosphatidylglycerol(PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells(By similarity).

Molecular Weight: 21-23 kDa

Gene ID: 114971

UniProt: Q8WUK0

Pathways: Inositol Metabolic Process