RAB7B antibody

Catalog No. ABIN7118233

This Rabbit Polyclonal antibody specifically detects RAB7B in WB and ELISA. It exhibits reactivity toward Human and Mouse.

Quick Overview for RAB7B antibody (ABIN7118233)

Target: RAB7B (RAB7B, Member RAS Oncogene Family (RAB7B))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAB7B antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-RAB7B Antibody

Purpose: RAB7B antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: RAB7B, member RAS oncogene family

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for RAB7B

Target: RAB7B (RAB7B, Member RAS Oncogene Family (RAB7B))

Alternative Name: RAB7B

Background:

Synonyms: Ras-related protein Rab-7b|RAB7B

Background: Controls vesicular trafficking from endosomes to the trans-Golgi network(TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF-and EGFR degradation pathway.

Molecular Weight: 23 kDa

Gene ID: 338382

UniProt: Q96AH8