RECQL5 antibody

Catalog No. ABIN7118358

The Rabbit Polyclonal anti-RECQL5 antibody (ABIN7118358) specifically detects RECQL5 in WB, ELISA, IF and IHC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for RECQL5 antibody (ABIN7118358)

Target: RECQL5 (RecQ Protein-Like 5 (RECQL5))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RECQL5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC)

Product Details anti-RECQL5 Antibody

Purpose: RECQL5 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: RecQ protein-like 5

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for RECQL5

Target: RECQL5 (RecQ Protein-Like 5 (RECQL5))

Alternative Name: RECQL5

Background:

Synonyms: ATP-dependent DNA helicase Q5|DNA helicase, RecQ-like type 5 (RecQ5)|RecQ protein-like 5|RECQL5|RECQ5

Background: Isoform beta is a DNA helicase that plays an important role in DNA replication, transcription and repair. Inhibits elongation of stalled transcripts at DNA damage sites by binding to the RNA polymerase II subunit POLR2A and blocking the TCEA1 binding site. Required for mitotic chromosome separation after cross-over events and cell cycle progress. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination.

Molecular Weight: 50-60 kDa

Gene ID: 9400

UniProt: O94762