RGMA antibody

Catalog No. ABIN7118468

The Rabbit Polyclonal anti-RGMA antibody has been validated for WB, ELISA and IP. It is suitable to detect RGMA in samples from Human, Mouse and Rat.

Quick Overview for RGMA antibody (ABIN7118468)

Target: RGMA (RGM Domain Family, Member A (RGMA))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RGMA antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Product Details anti-RGMA Antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: RGM domain family, member A

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:200-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for RGMA

Target: RGMA (RGM Domain Family, Member A (RGMA))

Alternative Name: RGMA

Background: Synonyms:RGM Background:Member of the repulsive guidance molecule(RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein(BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.

Molecular Weight: 49 kDa

Gene ID: 56963

UniProt: Q96B86

Pathways: Tube Formation