ARHGEF7 antibody

Catalog No. ABIN7118495

The Rabbit Polyclonal anti-ARHGEF7 antibody has been validated for WB, ELISA and IP. It is suitable to detect ARHGEF7 in samples from Human, Rat and Mouse.

Quick Overview for ARHGEF7 antibody (ABIN7118495)

Target: ARHGEF7 (rho Guanine Nucleotide Exchange Factor (GEF) 7 (ARHGEF7))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARHGEF7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Product Details anti-ARHGEF7 Antibody

Purpose: ARHGEF7 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: Rho guanine nucleotide exchange factor(GEF) 7

Isotype: IgG

Application Details

Application Notes: WB: 1:1000-1:4000, IP: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for ARHGEF7

Target: ARHGEF7 (rho Guanine Nucleotide Exchange Factor (GEF) 7 (ARHGEF7))

Alternative Name: ARHGEF7

Background:

Synonyms: Rho guanine nucleotide exchange factor 7|Beta-Pix|COOL-1|PAK-interacting exchange factor beta|p85|ARHGEF7|COOL1|KIAA0142|P85SPR|PAK3BP|PIXB

Background: Acts as a RAC1 guanine nucleotide exchange factor(GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions(By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.

Molecular Weight: 70 kDa

Gene ID: 8874

UniProt: Q14155

Pathways: EGFR Signaling Pathway, Neurotrophin Signaling Pathway, EGFR Downregulation