ARHGEF7 antibody

Catalog No. ABIN1169227

This Rabbit Polyclonal antibody specifically detects ARHGEF7 in WB, ELISA and ICC. It exhibits reactivity toward Human, Rat and Mouse.It has been mentioned in 1 publication

Quick Overview for ARHGEF7 antibody (ABIN1169227)

Target: ARHGEF7 (rho Guanine Nucleotide Exchange Factor (GEF) 7 (ARHGEF7))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ARHGEF7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Product Details anti-ARHGEF7 Antibody

Purpose: anti-beta-Pix (mouse), pAb

Specificity: Recognizes the multiple splice variants of human, mouse and rat beta-Pix a, b, bL, c and d-isoforms. Cross-reacts with human and rat beta-Pix.

Cross-Reactivity (Details): Cross-reacts with human and rat beta-Pix.

Characteristics: Polyclonal Antibody. Recognizes the multiple splice variants of human, mouse and rat beta-Pix a, b, bL, c and d-isoforms. Cross-reacts with human and rat beta-Pix. Source: Rabbit. Applications: ELISA, ICC, WB. Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives. beta-PIX acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. It interacts with PAK kinases through the SH3 domain. It may function as a positive regulator of apoptosis and is involved in cell migration. It is expressed with high levels in the central nervous system.

Sterility: 0.2 μm filtered

Immunogen: Recombinant beta-Pix SH3 domain.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.2μm-filtered solution in PBS, pH 7.4.

Preservative: Without preservative

Handling Advice: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment:

+4°C

-20°C

Stable for at least 6 months after receipt when stored at -20°C.

Expiry Date: 6 months

References for anti-ARHGEF7 antibody (ABIN1169227)

Oh, Yoo, Jo, Song, Kim, Park: "Cloning of a SH3 domain-containing proline-rich protein, p85SPR, and its localization in focal adhesion." in: Biochemical and biophysical research communications, Vol. 235, Issue 3, pp. 794-8, (1997) (PubMed).

Target Details for ARHGEF7

Target: ARHGEF7 (rho Guanine Nucleotide Exchange Factor (GEF) 7 (ARHGEF7))

Alternative Name: beta-Pix

Background:

Alternate Names/Synonyms: ARHGEF7, Rho Guanine Nucleotide Exchange Factor 7, PAK-interacting Exchange Factor beta, p85SPR, COOL-1

Product Description: beta-PIX acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. It interacts with PAK kinases through the SH3 domain. It may function as a positive regulator of apoptosis and is involved in cell migration. It is expressed with high levels in the central nervous system.

UniProt: Q9ES28

Pathways: EGFR Signaling Pathway, Neurotrophin Signaling Pathway, EGFR Downregulation