RNF212 antibody

Catalog No. ABIN7118647

This Rabbit Polyclonal antibody specifically detects RNF212 in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for RNF212 antibody (ABIN7118647)

Target: RNF212 (Ring Finger Protein 212 (RNF212))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RNF212 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-RNF212 Antibody

Purpose: RNF212 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: ring finger protein 212

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for RNF212

Target: RNF212 (Ring Finger Protein 212 (RNF212))

Alternative Name: RNF212

Background:

Synonyms: Probable E3 SUMO-protein ligase RNF212|Probable E3 SUMO-protein transferase RNF212|RING finger protein 212|RNF212

Background: SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins(MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination(By similarity).

Molecular Weight: 22 kDa

Gene ID: 285498

UniProt: Q495C1