RBM14 antibody

Catalog No. ABIN7118671

This Rabbit Polyclonal antibody specifically detects RBM14 in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for RBM14 antibody (ABIN7118671)

Target: RBM14 (RNA Binding Motif Protein 14 (RBM14))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RBM14 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-RBM14 Antibody

Purpose: RBM14 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: RNA binding motif protein 14

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for RBM14

Target: RBM14 (RNA Binding Motif Protein 14 (RBM14))

Alternative Name: RBM14

Background:

Synonyms: RNA-binding protein 14|Paraspeckle protein 2 (PSP2)|RNA-binding motif protein 14|RRM-containing coactivator activator/modulator|Synaptotagmin-interacting protein (SYT-interacting protein)|RBM14|SIP

Background: Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1(PubMed:11443112). Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CENPJ complex(which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CENPJ(PubMed:25385835).

Molecular Weight: 70-75 kDa

Gene ID: 10432

UniProt: Q96PK6

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway