Septin 2 antibody

Catalog No. ABIN7118880

This anti-Septin 2 antibody is a Mouse Monoclonal antibody detecting Septin 2 in WB, ELISA, IHC and IF. Suitable for Human, Mouse and Rat.

Quick Overview for Septin 2 antibody (ABIN7118880)

Target: Septin 2 (SEPT2)

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Septin 2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Clone: 8H4

Product Details anti-Septin 2 Antibody

Purification: Protein A+G purification

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: septin 2

Isotype: IgG1

Application Details

Application Notes: WB: 1:20000-1:200000, IHC: 1:50-1:2000, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for Septin 2

Target: Septin 2 (SEPT2)

Alternative Name: SEPT2

Background: Synonyms:hNedd5, NEDD 5, NEDD5, SEPT2, SEPT2/septin 2, septin 2, septin2 Background:Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex(also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.

Molecular Weight: 43 kDa

Gene ID: 4735

UniProt: Q15019