SETD1B antibody (AA 350-459)

Catalog No. ABIN7118990

The Rabbit Polyclonal anti-SETD1B antibody is suitable to detect SETD1B in samples from Human and Mouse. It has been validated for WB, ELISA, IHC, IF and IP.

Quick Overview for SETD1B antibody (AA 350-459) (ABIN7118990)

Target: SETD1B (SET Domain Containing 1B (SETD1B))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SETD1B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Product Details anti-SETD1B Antibody

Binding Specificity: AA 350-459

Purpose: SETD1B antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: peptide(350-459aa)

Immunogen: SET domain containing 1B

Isotype: IgG

Application Details

Application Notes: WB: 1:200-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:50-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for SETD1B

Target: SETD1B (SET Domain Containing 1B (SETD1B))

Alternative Name: SETD1B

Background:

Synonyms: Histone-lysine N-methyltransferase SETD1B|Lysine N-methyltransferase 2G|SET domain-containing protein 1B (hSET1B)|SETD1B|KIAA1076|KMT2G|SET1B

Background: Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase(HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro.

Molecular Weight: 260 kDa

Gene ID: 23067

UniProt: Q9UPS6