SPPL2A antibody

Catalog No. ABIN7119061

This Rabbit Polyclonal antibody specifically detects SPPL2A in ELISA, WB and IHC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for SPPL2A antibody (ABIN7119061)

Target: SPPL2A (Signal Peptide Peptidase-Like 2A (SPPL2A))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPPL2A antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-SPPL2A Antibody

Purpose: SPPL2A antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: signal peptide peptidase-like 2A

Isotype: IgG

Application Details

Application Notes: WB: 1:200-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for SPPL2A

Target: SPPL2A (Signal Peptide Peptidase-Like 2A (SPPL2A))

Alternative Name: SPPL2A

Background:

Synonyms: Signal peptide peptidase-like 2A (SPP-like 2A, SPPL2a)|Intramembrane protease 3 (IMP-3)|Presenilin-like protein 2|SPPL2A|IMP3|PSL2

Background: SPPL2A(Signal peptide peptidase-like 2A) is also named as IMP3(Intramembrane protease 3), PSL2(Presenilin-like protein 2) and belongs to the peptidase A22B family. It is an aspartyl intramembrane protease, has been implicated in the proteolysis of TNF-alpha, Fas Ligand and Bri2 and endogenous signal-peptide-peptidase-like2A(SPPL2a) is localised in lysosomes/late endosomes(PMID:21896273).

Molecular Weight: 58 kDa

UniProt: Q8TCT8