SMN1 antibody

Catalog No. ABIN7119175

This Mouse Monoclonal antibody specifically detects SMN1 in WB, ELISA and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for SMN1 antibody (ABIN7119175)

Target: SMN1 (Survival of Motor Neuron 1, Telomeric (SMN1))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This SMN1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Clone: 3D2

Product Details anti-SMN1 Antibody

Purpose: SMN1 antibody

Purification: Protein A+G purification

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: survival of motor neuron 2, centromeric

Isotype: IgG1

Application Details

Application Notes: WB: 1:1000-1:6000, IF: 1:50-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for SMN1

Target: SMN1 (Survival of Motor Neuron 1, Telomeric (SMN1))

Alternative Name: SMN1

Background:

Synonyms: Survival motor neuron protein|Component of gems 1|Gemin-1|SMN1|SMN|SMNT

Background: The survival of motor neurons(SMN) genes are the disease genes of spinal muscular atrophy(SMA), a common motor neuron degenerative disease. The level of SMN protein correlates with phenotypic severity of SMA. SMA patients lack a functional SMN1 gene, but they possess an intact SMN2 gene, which though nearly identical to SMN1, is only partially functional, because a large majority of SMN2 transcripts lack exon 7, resulting in production of a truncated, less stable SMN protein. This antibody can recognize human,mouse and rat SMN.

Molecular Weight: 38 kDa

UniProt: Q16637

Pathways: Ribonucleoprotein Complex Subunit Organization