SLC22A1 antibody

Catalog No. ABIN7119250

This Rabbit Polyclonal antibody specifically detects SLC22A1 in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for SLC22A1 antibody (ABIN7119250)

Target: SLC22A1 (Solute Carrier Family 22 (Organic Cation Transporter), Member 1 (SLC22A1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC22A1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-SLC22A1 Antibody

Purpose: SLC22A1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: solute carrier family 22(organic cation transporter), member 1

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for SLC22A1

Target: SLC22A1 (Solute Carrier Family 22 (Organic Cation Transporter), Member 1 (SLC22A1))

Alternative Name: SLC22A1

Background:

Synonyms: Solute carrier family 22 member 1|Organic cation transporter 1 (hOCT1)|SLC22A1|45566

Background: Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium(MPP), tetraethylammonium(TEA), N-1-methylnicotinamide(NMN), 4-(4-(dimethylamino)styryl)-N-methylpyridinium(ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium(TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH -independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin-dependent kinase II and LCK tyrosine kinase.

Molecular Weight: 61-67 kDa

Gene ID: 6580

UniProt: O15245

Pathways: Hormone Transport