SFPQ antibody

Catalog No. ABIN7119440

The Rabbit Polyclonal anti-SFPQ antibody has been validated for WB, IHC and ELISA. It is suitable to detect SFPQ in samples from Human, Mouse and Rat.

Quick Overview for SFPQ antibody (ABIN7119440)

Target: SFPQ (Splicing Factor Proline/glutamine-Ric (SFPQ))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SFPQ antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-SFPQ Antibody

Purpose: SFPQ antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: splicing factor proline/glutamine-rich (polypyrimidine tract binding protein associated)

Isotype: IgG

Application Details

Application Notes: WB: 1:500 - 1:1000, IHC: 1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for SFPQ

Target: SFPQ (Splicing Factor Proline/glutamine-Ric (SFPQ))

Alternative Name: SFPQ

Background:

Synonyms: Splicing factor, proline- and glutamine-rich|100 kDa DNA-pairing protein (hPOMp100)|DNA-binding p52/p100 complex, 100 kDa subunit|Polypyrimidine tract-binding protein-associated-splicing factor (PSF, PTB-associated-splicing factor)|SFPQ|PSF

Background: SFPQ, also named PSF, encodes a nuclear factor implicated in the splicing and regulation of gene expression. SFPQ probably forms a heteromer with NONO and participates in DNA pairing and DNA break repair program. Very recently SFPQ was identified as a downstream target of tau, complete nuclear depletion and cytoplasmic accumulation of SFPQ were shown in the neurons and astrocytes of brains with Alzheimer's disease (AD), more strikingly, reduced SFPQ levels may progress together with tau pathology, these observation strongly suggests the important role of SFPQ pathology in neurodegenerative diseases including AD. SFPQ protein may appears as 47 kDa, 52 kDa or 100 kDa molecules in various cell types. This antibody is a rabbit polyclonal antibody raised against the N-terminal of human SFPQ.

Molecular Weight: 115 kDa

Gene ID: 6421

UniProt: P23246