SKAP2 antibody

Catalog No. ABIN7119461

The Rabbit Polyclonal anti-SKAP2 antibody has been validated for WB, ELISA, IHC and IF. It is suitable to detect SKAP2 in samples from Human, Mouse and Rat.

Quick Overview for SKAP2 antibody (ABIN7119461)

Target: SKAP2 (Src Kinase Associated Phosphoprotein 2 (SKAP2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SKAP2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-SKAP2 Antibody

Purpose: SKAP2 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: src kinase associated phosphoprotein 2

Isotype: IgG

Application Details

Application Notes: WB: 1:500 - 1:2000, IHC: 1:50 - 1:100, IF: 1:50 - 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for SKAP2

Target: SKAP2 (Src Kinase Associated Phosphoprotein 2 (SKAP2))

Alternative Name: SKAP2

Background:

Synonyms: Src kinase-associated phosphoprotein 2|Pyk2/RAFTK-associated protein|Retinoic acid-induced protein 70|SKAP55 homolog (SKAP-55HOM, SKAP-HOM)|Src family-associated phosphoprotein 2|Src kinase-associated phosphoprotein 55-related protein|Src-associated adapter protein with PH and SH3 domains|SKAP2|PRAP|RA70|SAPS|SCAP2|SKAP55R

Background: The protein encoded by this gene shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This protein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molecular Weight: 50 kDa

Gene ID: 8935

UniProt: O75563