STIM1 antibody

Catalog No. ABIN7119554

The Rabbit Polyclonal anti-STIM1 antibody has been validated for WB, IHC, ELISA, IP, IF and FACS. It is suitable to detect STIM1 in samples from Human, Rat and Mouse.

Quick Overview for STIM1 antibody (ABIN7119554)

Target: STIM1 (Stromal Interaction Molecule 1 (STIM1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This STIM1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-STIM1 Antibody

Purpose: STIM1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: stromal interaction molecule 1

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:1000, IP: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:10-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for STIM1

Target: STIM1 (Stromal Interaction Molecule 1 (STIM1))

Alternative Name: STIM1

Background:

Synonyms: Stromal interaction molecule 1|STIM1|GOK

Background: STIM1, also named as GOK, is an ER Ca2+ sensor. Upon Ca2+ store depletion, STIM1 clusters at ER-plasma membrane junctions where it interacts with and gates Ca2+-permeable Orai1 ion channels. STIM1 is implicated in tumor growth suppression and stromal-haematopoietic cell interactions. Defacts in STIM1 gene can cause immune dysfunction with impaired T-cell activation. STIM1 can inhibit L-type voltage-gated Ca(2+) channels in neurons. Temperature is an important regulator of STIM1 function.The MW of STIM1 is about 80-90 kDa which may be due to the phosphorylation or glycosylation forms. This antibody is rabbit polyclonal antibody raised against the N-terminal of human STIM1.

Molecular Weight: 80 kDa

Gene ID: 6786

UniProt: Q13586

Pathways: TCR Signaling, BCR Signaling