SMC5 antibody

Catalog No. ABIN7119560

The Rabbit Polyclonal anti-SMC5 antibody has been validated for WB and ELISA. It is suitable to detect SMC5 in samples from Human, Rat and Mouse.

Quick Overview for SMC5 antibody (ABIN7119560)

Target: SMC5 (Structural Maintenance of Chromosomes 5 (SMC5))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMC5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-SMC5 Antibody

Purpose: SMC5 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: structural maintenance of chromosomes 5

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for SMC5

Target: SMC5 (Structural Maintenance of Chromosomes 5 (SMC5))

Alternative Name: SMC5

Background:

Synonyms: Structural maintenance of chromosomes protein 5 (SMC protein 5, SMC-5, hSMC5)|SMC5|KIAA0594|SMC5L1

Background: Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT(alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex(telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies(APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression, the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome(PubMed:26983541).

Molecular Weight: 120-130 kDa

Gene ID: 23137

UniProt: Q8IY18