SYTL2 antibody

Catalog No. ABIN7119674

The Rabbit Polyclonal anti-SYTL2 antibody is suitable to detect SYTL2 in samples from Human, Mouse and Rat. It has been validated for WB, IHC and ELISA.

Quick Overview for SYTL2 antibody (ABIN7119674)

Target: SYTL2 (Synaptotagmin Like Protein 2 (SYTL2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SYTL2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-SYTL2 Antibody

Purpose: SYTL2 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: synaptotagmin-like 2

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for SYTL2

Target: SYTL2 (Synaptotagmin Like Protein 2 (SYTL2))

Alternative Name: SYTL2

Background:

Synonyms: Synaptotagmin-like protein 2|Breast cancer-associated antigen SGA-72M|Exophilin-4|SYTL2|KIAA1597|SGA72M|SLP2|SLP2A

Background: Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine(PS) and phosphatidylinositol-4,5-bisphosphate(PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive.

Molecular Weight: 100-105 kDa

Gene ID: 54843

UniProt: Q9HCH5