TBC1D17 antibody (AA 1-350)

Catalog No. ABIN7119799

This Rabbit Polyclonal antibody specifically detects TBC1D17 in WB, ELISA, IHC and IF. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for TBC1D17 antibody (AA 1-350) (ABIN7119799)

Target: TBC1D17 (TBC1 Domain Family, Member 17 (TBC1D17))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TBC1D17 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-TBC1D17 Antibody

Binding Specificity: AA 1-350

Purpose: TBC1D17 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 1-350aa

Immunogen: TBC1 domain family, member 17

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for TBC1D17

Target: TBC1D17 (TBC1 Domain Family, Member 17 (TBC1D17))

Alternative Name: TBC1D17

Background:

Synonyms: TBC1 domain family member 17|TBC1D17

Background: Probable GTPase-activating protein for Rab8, its transient association with Rab8 is mediated by OPTN. Inhibits Rab8-mediated endocytic trafficking, such as of transferrin receptor(TfR) and reduces Rab8 recruitnment to tubules emanating from the endocytic recycling compartment(ERC). Involved in regulation of autophagy. Mediates inhibition of autophagy caused by the OPTN variant GLC1E LYS-50, the function requires its catalytic activity, however, the involved Rab is not known.

Molecular Weight: 73-100 kDa

Gene ID: 79735

UniProt: Q9HA65