TEAD2 antibody

Catalog No. ABIN7119811

This Rabbit Polyclonal antibody specifically detects TEAD2 in ELISA and WB. It exhibits reactivity toward Human and Mouse.

Quick Overview for TEAD2 antibody (ABIN7119811)

Target: TEAD2 (TEA Domain Family Member 2 (TEAD2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TEAD2 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-TEAD2 Antibody

Purpose: TEAD2 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: TEA domain family member 2

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for TEAD2

Target: TEAD2 (TEA Domain Family Member 2 (TEAD2))

Alternative Name: TEAD2

Background:

Synonyms: Transcriptional enhancer factor TEF-4|TEA domain family member 2 (TEAD-2)|TEAD2|TEF4

Background: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition(EMT) induction. Binds to the SPH and GT-IIC 'enhansons'(5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.

Molecular Weight: 55-65 kDa

Gene ID: 8463

UniProt: Q15562

Pathways: Regulation of Lipid Metabolism by PPARalpha, Tube Formation