TEAD4 antibody

Catalog No. ABIN7119813

The Rabbit Polyclonal anti-TEAD4 antibody (ABIN7119813) specifically detects TEAD4 in WB, ELISA and IP. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for TEAD4 antibody (ABIN7119813)

Target: TEAD4 (TEA Domain Family Member 4 (TEAD4))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TEAD4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Product Details anti-TEAD4 Antibody

Purpose: TEAD4 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: TEA domain family member 4

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:200-1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for TEAD4

Target: TEAD4 (TEA Domain Family Member 4 (TEAD4))

Alternative Name: TEAD4

Background:

Synonyms: Transcriptional enhancer factor TEF-3|TEA domain family member 4 (TEAD-4)|Transcription factor 13-like 1|Transcription factor RTEF-1|TEAD4|RTEF1|TCF13L1|TEF3

Background: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition(EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons'(5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.

Molecular Weight: 50-55 kDa

Gene ID: 7004

UniProt: Q15561

Pathways: Regulation of Lipid Metabolism by PPARalpha