THOC7 antibody

Catalog No. ABIN7119929

The Rabbit Polyclonal anti-THOC7 antibody has been validated for WB, ELISA and IHC. It is suitable to detect THOC7 in samples from Human, Mouse and Rat.

Quick Overview for THOC7 antibody (ABIN7119929)

Target: THOC7 (THO Complex 7 (THOC7))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This THOC7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-THOC7 Antibody

Purpose: THOC7 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: THO complex 7 homolog(Drosophila)

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for THOC7

Target: THOC7 (THO Complex 7 (THOC7))

Alternative Name: THOC7

Background:

Synonyms: THO complex subunit 7 homolog|Functional spliceosome-associated protein 24 (fSAP24)|Ngg1-interacting factor 3-like protein 1-binding protein 1 (NIF3L1-binding protein 1)|hTREX30|THOC7|NIF3L1BP1

Background: Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex(EJC) and is recruited in a splicing-and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus(KSHV) intronless mRNAs and infectious virus production.

Molecular Weight: 24 kDa

Gene ID: 80145

UniProt: Q6I9Y2