TRIP10 antibody

Catalog No. ABIN7119955

This Rabbit Polyclonal antibody specifically detects TRIP10 in WB, ELISA and IF. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for TRIP10 antibody (ABIN7119955)

Target: TRIP10 (Thyroid Hormone Receptor Interactor 10 (TRIP10))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIP10 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-TRIP10 Antibody

Purpose: TRIP10 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: thyroid hormone receptor interactor 10

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:5000, IP: 1:500-1:5000, IF: 1:10-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for TRIP10

Target: TRIP10 (Thyroid Hormone Receptor Interactor 10 (TRIP10))

Alternative Name: TRIP10

Background:

Synonyms: Cdc42-interacting protein 4|Protein Felic|Salt tolerant protein (hSTP)|Thyroid receptor-interacting protein 10 (TR-interacting protein 10, TRIP-10)|TRIP10|CIP4|STOT|STP

Background: Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling(By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.

Molecular Weight: 75-85 kDa

Gene ID: 9322

UniProt: Q15642