TRAF3IP1 antibody

Catalog No. ABIN7119988

This Rabbit Polyclonal antibody specifically detects TRAF3IP1 in WB, ELISA, IHC, IF and IP. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for TRAF3IP1 antibody (ABIN7119988)

Target: TRAF3IP1 (TNF Receptor-Associated Factor 3 Interacting Protein 1 (TRAF3IP1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRAF3IP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Product Details anti-TRAF3IP1 Antibody

Purpose: TRAF3IP1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: TNF receptor-associated factor 3 interacting protein 1

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:200-1:1000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for TRAF3IP1

Target: TRAF3IP1 (TNF Receptor-Associated Factor 3 Interacting Protein 1 (TRAF3IP1))

Alternative Name: TRAF3IP1

Background:

Synonyms: TRAF3-interacting protein 1|Interleukin-13 receptor alpha 1-binding protein 1|Intraflagellar transport protein 54 homolog|Microtubule-interacting protein associated with TRAF3 (MIP-T3)|TRAF3IP1|IFT54|MIPT3

Background: Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules. Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels(PubMed:26487268). Involved in ciliogenesis(By similarity).

Molecular Weight: 83 kDa

Gene ID: 26146

UniProt: Q8TDR0

Pathways: Hedgehog Signaling