TFE3 antibody (AA 1-300)

Catalog No. ABIN7120074

This anti-TFE3 antibody is a Rabbit Polyclonal antibody detecting TFE3 in WB, ELISA, IHC and IP. Suitable for Human, Mouse and Rat.

Quick Overview for TFE3 antibody (AA 1-300) (ABIN7120074)

Target: TFE3 (Transcription Factor E3 (TFE3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TFE3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Product Details anti-TFE3 Antibody

Binding Specificity: AA 1-300

Purpose: TFE3 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 1-300aa

Immunogen: transcription factor binding to IGHM enhancer 3

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:5000, IP: 1:200-1:2000, IHC: 1:50-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for TFE3

Target: TFE3 (Transcription Factor E3 (TFE3))

Alternative Name: TFE3

Background:

Synonyms: Transcription factor E3|Class E basic helix-loop-helix protein 33 (bHLHe33)|TFE3|BHLHE33

Background: Transcription factor that specifically recognizes and binds E-box sequences(5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/MLTF site.

Molecular Weight: 65 kDa

Gene ID: 7030

UniProt: P19532