TIMM8A/DDP antibody

Catalog No. ABIN7120157

The Rabbit Polyclonal anti-TIMM8A/DDP antibody has been validated for WB and ELISA. It is suitable to detect TIMM8A/DDP in samples from Human, Mouse and Rat.

Quick Overview for TIMM8A/DDP antibody (ABIN7120157)

Target: TIMM8A/DDP (TIMM8A) (Translocase of Inner Mitochondrial Membrane 8A (TIMM8A))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TIMM8A/DDP antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-TIMM8A/DDP Antibody

Purpose: TIMM8A antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: translocase of inner mitochondrial membrane 8 homolog A(yeast)

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for TIMM8A/DDP

Target: TIMM8A/DDP (TIMM8A) (Translocase of Inner Mitochondrial Membrane 8A (TIMM8A))

Alternative Name: TIMM8A

Background:

Synonyms: Mitochondrial import inner membrane translocase subunit Tim8 A|Deafness dystonia protein 1|X-linked deafness dystonia protein|TIMM8A|DDP|DDP1|TIM8A

Background: Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery(SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. Probably necessary for normal neurologic development.

Molecular Weight: 11 kDa

Gene ID: 1678

UniProt: O60220