TRIM37 antibody

Catalog No. ABIN7120286

The Rabbit Polyclonal anti-TRIM37 antibody has been validated for ELISA, WB, IHC and IF. It is suitable to detect TRIM37 in samples from Human and Mouse.

Quick Overview for TRIM37 antibody (ABIN7120286)

Target: TRIM37 (Tripartite Motif Containing 37 (TRIM37))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRIM37 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-TRIM37 Antibody

Purpose: TRIM37 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: tripartite motif-containing 37

Isotype: IgG

Application Details

Application Notes: WB: 1:200-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for TRIM37

Target: TRIM37 (Tripartite Motif Containing 37 (TRIM37))

Alternative Name: TRIM37

Background:

Synonyms: E3 ubiquitin-protein ligase TRIM37|Mulibrey nanism protein|RING-type E3 ubiquitin transferase TRIM37|Tripartite motif-containing protein 37|TRIM37|KIAA0898|MUL|POB1

Background: E3 ubiquitin-protein ligase required to prevent centriole reduplication(PubMed:15885686, PubMed:23769972). Probably acts by ubiquitinating positive regulators of centriole reduplication(PubMed:23769972). Mediates monoubiquitination of 'Lys-119' of histone H2A(H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group(PcG) multiprotein PRC2-like complex and mediates repression of target genes(PubMed:25470042). Has anti-HIV activity(PubMed:24317724).

Molecular Weight: 100 kDa, 130 kDa

Gene ID: 4591

UniProt: O94972