TBCD antibody

Catalog No. ABIN7120359

The Rabbit Polyclonal anti-TBCD antibody (ABIN7120359) specifically detects TBCD in WB, ELISA and IP. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for TBCD antibody (ABIN7120359)

Target: TBCD (Tubulin Folding Cofactor D (TBCD))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TBCD antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Product Details anti-TBCD Antibody

Purpose: TBCD antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: tubulin folding cofactor D

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IP: 1:200-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for TBCD

Target: TBCD (Tubulin Folding Cofactor D (TBCD))

Alternative Name: TBCD

Background:

Synonyms: Tubulin-specific chaperone D|Beta-tubulin cofactor D (tfcD)|SSD-1|Tubulin-folding cofactor D|TBCD|KIAA0988|SSD1|TFCD

Background: Tubulin-folding protein, involved in the first step of the tubulin folding pathway. Modulates microtubule dynamics by capturing GTP-bound beta-tubulin(TUBB). Acts as a GTPase-activating protein(GAP) for ARL2. Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane.

Molecular Weight: 130 kDa

Gene ID: 6904

UniProt: Q9BTW9

Pathways: Cell-Cell Junction Organization