Urm1 antibody

Catalog No. ABIN7120488

This anti-Urm1 antibody is a Rabbit Polyclonal antibody detecting Urm1 in WB, ELISA and IHC. Suitable for Human, Rat and Mouse.

Quick Overview for Urm1 antibody (ABIN7120488)

Target: Urm1 (Ubiquitin Related Modifier 1 (Urm1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Urm1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-Urm1 Antibody

Purpose: URM1 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: ubiquitin related modifier 1 homolog

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:5000, IHC:1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for Urm1

Target: Urm1 (Ubiquitin Related Modifier 1 (Urm1))

Alternative Name: URM1

Background:

Synonyms: Ubiquitin-related modifier 1|URM1|C9orf74

Background: Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated(-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein(UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.

Molecular Weight: 11 kDa

Gene ID: 81605

UniProt: Q9BTM9