USP1 antibody (AA 430-785)

Catalog No. ABIN7120490

The Mouse Monoclonal anti-USP1 antibody has been validated for WB, ELISA and IHC. It is suitable to detect USP1 in samples from Human.

Quick Overview for USP1 antibody (AA 430-785) (ABIN7120490)

Target: USP1 (Ubiquitin Specific Peptidase 1 (USP1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This USP1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Clone: 8F7

Product Details anti-USP1 Antibody

Binding Specificity: AA 430-785

Purpose: USP1 antibody

Purification: Protein A+G purification

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 430-785aa

Immunogen: ubiquitin specific peptidase 1

Isotype: IgG1

Application Details

Application Notes: WB: 1:1000-1:10000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for USP1

Target: USP1 (Ubiquitin Specific Peptidase 1 (USP1))

Alternative Name: USP1

Background:

Synonyms: Ubiquitin carboxyl-terminal hydrolase 1|Deubiquitinating enzyme 1 (hUBP)|Ubiquitin thioesterase 1|Ubiquitin-specific-processing protease 1|Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment|USP1

Background: Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2(PubMed:15694335). Also involved in PCNA-mediated translesion synthesis(TLS) by deubiquitinating monoubiquitinated PCNA(PubMed:16531995). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity(PubMed:18082604, PubMed:26388029).

Molecular Weight: 90 kDa

Gene ID: 7398

UniProt: O94782