USP34 antibody

Catalog No. ABIN7120515

This anti-USP34 antibody is a Rabbit Polyclonal antibody detecting USP34 in WB, ELISA and IHC. Suitable for Human and Mouse.

Quick Overview for USP34 antibody (ABIN7120515)

Target: USP34 (Ubiquitin Specific Peptidase 34 (USP34))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This USP34 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-USP34 Antibody

Purpose: USP34 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: ubiquitin specific peptidase 34

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:5000, IP: 1:200-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for USP34

Target: USP34 (Ubiquitin Specific Peptidase 34 (USP34))

Alternative Name: USP34

Background:

Synonyms: Ubiquitin carboxyl-terminal hydrolase 34|Deubiquitinating enzyme 34|Ubiquitin thioesterase 34|Ubiquitin-specific-processing protease 34|USP34|KIAA0570|KIAA0729

Background: Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin(CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.

Molecular Weight: 47 kDa

Gene ID: 9736

UniProt: Q70CQ2