UXT antibody (AA 1-157)

Catalog No. ABIN7120577

The Rabbit Polyclonal anti-UXT antibody is suitable to detect UXT in samples from Human, Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for UXT antibody (AA 1-157) (ABIN7120577)

Target: UXT (Ubiquitously-Expressed, Prefoldin-Like Chaperone (UXT))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UXT antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-UXT Antibody

Binding Specificity: AA 1-157

Purpose: UXT antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 1-157aa

Immunogen: ubiquitously-expressed transcript

Isotype: IgG

Application Details

Application Notes: WB: 1:200-1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for UXT

Target: UXT (Ubiquitously-Expressed, Prefoldin-Like Chaperone (UXT))

Alternative Name: UXT

Background:

Synonyms: Protein UXT|Androgen receptor trapped clone 27 protein (ART-27)|Ubiquitously expressed transcript protein|UXT

Background: Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor transcription(AR). AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation(PubMed:11854421). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling(PubMed:11827465). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC(PubMed:17554592). May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function(PubMed:17620405). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM(PubMed:17635584). Together with URI1, associates with chromatin to the NKX3-1 promoter region.

Molecular Weight: 18 kDa

Gene ID: 8409

UniProt: Q9UBK9

Pathways: Unfolded Protein Response