UNC13A/Munc13-1 antibody

Catalog No. ABIN7120613

The Rabbit Polyclonal anti-UNC13A/Munc13-1 antibody has been validated for WB and ELISA. It is suitable to detect UNC13A/Munc13-1 in samples from Human and Mouse.

Quick Overview for UNC13A/Munc13-1 antibody (ABIN7120613)

Target: UNC13A/Munc13-1 (UNC13A) (Unc-13 Homolog A (UNC13A))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UNC13A/Munc13-1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-UNC13A/Munc13-1 Antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: unc-13 homolog A(C. elegans)

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:5000, IP: 1:200-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for UNC13A/Munc13-1

Target: UNC13A/Munc13-1 (UNC13A) (Unc-13 Homolog A (UNC13A))

Alternative Name: UNC13A/Munc13-1

Background: Synonyms:KIAA1032, Munc13 1, Protein unc 13 homolog A, unc 13 homolog A(C. elegans), UNC13A Background:UNC13A, also named as KIAA1032, belongs to the unc-13 family. It plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. UNC13A is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool(RRP). It is essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. UNC13A is also involved in secretory granule priming in insulin secretion. The antibody is specific to UNC13A.

Molecular Weight: 193 kDa

Pathways: Skeletal Muscle Fiber Development, Synaptic Vesicle Exocytosis