VPS26A antibody

Catalog No. ABIN7120721

The Rabbit Polyclonal anti-VPS26A antibody has been validated for WB, ELISA, IHC and IF. It is suitable to detect VPS26A in samples from Human, Mouse and Rat.

Quick Overview for VPS26A antibody (ABIN7120721)

Target: VPS26A (Vacuolar Protein Sorting-Associated Protein 26A (VPS26A))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This VPS26A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-VPS26A Antibody

Purpose: VPS26A antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: vacuolar protein sorting 26 homolog A

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months

Expiry Date: 12 months

Target Details for VPS26A

Target: VPS26A (Vacuolar Protein Sorting-Associated Protein 26A (VPS26A))

Alternative Name: VPS26A

Background:

Synonyms: Vacuolar protein sorting-associated protein 26A|Vesicle protein sorting 26A (hVPS26)|VPS26A|VPS26

Background: Acts as component of the retromer cargo-selective complex(CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network(TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins(Probable). The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5(Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R(PubMed:15078902, PubMed:15078903). Required to regulate transcytosis of the polymeric immunoglobulin receptor(pIgR-pIgA)(PubMed:15247922). Required for the endosomal localization of FAM21A(indicative for the WASH complex)(PubMed:22070227). Required for the endosomal localization of TBC1D5(PubMed:20923837). Mediates retromer cargo reognition of SORL1 and is involved in trafficking of SORL1 implicated in sorting and processing of APP(PubMed:22279231). Involved in retromer-independent lysosomal sorting of F2R(PubMed:16407403). Involved in recycling of ADRB2(PubMed:21602791). Enhances the affinity of SNX27 for PDZ-binding motifs in cargo proteins(By similarity).

Molecular Weight: 38 kDa

Gene ID: 9559

UniProt: O75436