WDR1 antibody

Catalog No. ABIN7120810

This Rabbit Polyclonal antibody specifically detects WDR1 in WB, IHC, ELISA and IP. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for WDR1 antibody (ABIN7120810)

Target: WDR1 (WD Repeat Domain 1 (WDR1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WDR1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP)

Product Details anti-WDR1 Antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: WD repeat domain 1

Isotype: IgG

Application Details

Application Notes: WB: 1:200-1:2000, IP: 1:200-1:2000, IHC: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for WDR1

Target: WDR1 (WD Repeat Domain 1 (WDR1))

Alternative Name: WDR1

Background: Synonyms:Actin interacting protein 1, AIP1, NORI 1, WD repeat containing protein 1, WD repeat domain 1, WDR1 Background:Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins(PubMed:15629458). Enhances cofilin-mediated actin severing(By similarity). Involved in cytokinesis. Involved in chemotactic cell migration by restricting lamellipodial membrane protrusions(PubMed:18494608). Involved in myocardium sarcomere organization. Required for cardiomyocyte growth and maintenance(By similarity). Involved in megakaryocyte maturation and platelet shedding. Required for the establishment of planar cell polarity(PCP) during follicular epithelium development and for cell shape changes during PCP, the function seems to implicate cooperation with CFL1 and/or DSTN/ADF. Involved in the generation/maintenance of cortical tension(By similarity). Involved in assembly and maintenance of epithelial apical cell junctions and plays a role in the organization of the perijunctional actomyosin belt(PubMed:25792565).

Molecular Weight: 66 kDa

Gene ID: 9948

UniProt: O75083

Pathways: Sensory Perception of Sound